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Welcome to the Nuclear Receptor DNA Binding Project

The nuclear receptor DNA binding project is dedicated to understanding DNA binding preferences of

human nuclear receptors and predicting potential binding sites (and hence target genes) in the human

genome for each nuclear receptor. This website serves as a centralized resource for DNA

binding specificity data of nuclear receptors based on 10,000's of unique sequences (12 to 17

nucleotides in length) from protein binding microarrays (PBMs), as well as disease-associated

SNPs in potential binding sites.

 
All data is publicly available and searchable from our aaSNP (affinity altering SNP) database http://nrmotif.ucr.edu/aaSNP/
 

News and Updates

06/12/17
PBM data for MYC/MAX are available for download. These data are described in:
Sequence-specific DNA binding by MYC/MAX to low-affinity non-E-box motifs.
Allevato M, Bolotin E, Grossman M, Mane-Padros D, Sladek FM, Martinez E. PLOS ONE, accepted June 2017

08/29/15
PBM data for human TCF4 and HNF4α are available for download. These data are described in
published by Vuong et al. in Mol Cell Biol. 2015.
 
03/01/12
PBM data for human RXRα and COUP-TFII are available for download. These data are described in
published by Fang et al. in Nucleic Acids Research, 2012.

02/01/10
PBM data for human HNF4α (NR2A1) are available for download. These data are described in
Integrated approach for the identification of human hepatocyte nuclear factor 4alpha target genes
using protein binding microarrays published by Bolotin et al. in Hepatology, 2010.
 
















       

Protein Binding Microarray

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spots
Beautiful Spots!!!

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motif
 
HNF4 Binding Motif Defined by PBM

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f4
HNF4 Binding Site Distribution

 

 

 

 

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