Welcome to the Nuclear Receptor DNA Binding Project
The nuclear receptor DNA binding project is dedicated to understanding DNA binding preferences of
human nuclear receptors and predicting potential binding sites (and hence target genes) in the human
genome for each nuclear receptor. This website serves as a centralized resource for DNA
binding specificity data of nuclear receptors based on 10,000's of unique sequences (12 to 17
nucleotides in length) from protein binding microarrays (PBMs), as well as disease-associated
SNPs in potential binding sites.
All data is publicly available and searchable from our aaSNP (affinity altering SNP) database http://nrmotif.ucr.edu/aaSNP/
News and Updates
PBM data for human TCF4 and HNF4α are available for download. These data are described in
Differential effects of HNF4α isoforms on tumor growth and TCF4/AP-1 interactions in human colorectal cancer cells
published by Vuong et al. in Mol Cell Biol. 2015.
PBM data for human RXRα and COUP-TFII are available for download. These data are described in
Identification of a binding motif specific to HNF4 by comparative analysis of multiple nuclear receptors
published by Fang et al. in Nucleic Acids Research, 2012.
PBM data for human HNF4α (NR2A1) are available for download. These data are described in
Integrated approach for the identification of human hepatocyte nuclear factor 4alpha target genes
using protein binding microarrays published by Bolotin et al. in Hepatology, 2010.
Protein Binding Microarray
HNF4 Binding Site Distribution